Brain and other central nervous system tumor statistics, 2021

Brain and other central nervous system (CNS) tumors are among the most fatal cancers account for substantial morbidity mortality in United States. Population-based data from Central Tumor Registry of States (a combined set National Program Cancer Registries [NPCR] Surveillance, Epidemiology, End Results [SEER] registries), NPCR, Vital Statistics System SEER program were analyzed to assess contemporary burden malignant nonmalignant brain CNS (hereafter brain) by histology, anatomic site, age, sex, race/ethnicity. Malignant tumor incidence rates declined 0.8% annually 2008 2017 all ages but increased 0.5% 0.7% per year children adolescents. is highest males non-Hispanic White individuals, whereas females Black individuals. Five-year relative survival between 1975 1977 2009 2015 23% 36%, with larger gains younger age groups. Less improvement older groups largely reflects a higher glioblastoma, which there have been few major advances prevention, early detection, treatment past 4 decades. Specifically, 5-year glioblastoma only 4% 7% during same time period. In addition, important disparities race/ethnicity remain childhood tumors, largest Black-White diffuse astrocytomas (75% vs 86% patients diagnosed 2009-2015) embryonal (59% 67%). Increased resources collection reporting timely consistent critical advancing research elucidate causes racial/ethnic differences occurrence, especially rarer subtypes understudied populations.